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doi: 10.3389/fonc.2025.1613751 Received 17 April 2025 Accepted 29 September 2025 Published 24 October 2025 Volume 15 - 2025 Edited by Stefano Cairo, Champions Oncology, Inc., United States Reviewed by Janith Ananda Seneviratne, Peter MacCallum Cancer Centre, Australia Nevim Aygun, Ege University, Trkiye Updates Copyright 2025 Epp, Egan, Poon, Abdul Aziz, Wynne, Chesler, Halasz and Kolch

The most common side effect of B12 injections is discomfort at the injection site

For those specifically interested in fat loss rather than muscle growth, AOD 9604 offers the relevant benefits without the problematic side effects of full-length growth hormone

Using tirzepatide alongside growth hormone secretagogues like ipamorelin or CJC-1295 may preserve lean mass better during aggressive fat loss