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However, related studies show that the activation of NRF2 alleviates the occurrence and development of AD by enhancing the antioxidant defense, improving mitochondrial function, inhibiting neuroinflammation, and inhibiting ferroptosis (Qu et al., 2020)

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Fasting for 36 h was shown to increase cerebral blood flow (CBF) in most human brain regions, although there were a few brain regions that showed increased CBF with satiation (Tataranni et al., 1999)

Given these uncertainties, it is important to reconsider how and when patch testing is best utilized in CHE